Thrombopoietin-receptor agonists in perioperative treatment of patients with chronic liver disease
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چکیده
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modern surgical techniques in treatment of patients with cleft lip & cleft palate
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15 صفحه اولWill thrombopoietin receptor agonists become a treatment option for pediatric chronic immune thrombocytopenia in the future?
2015 Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and increased bleeding tendency. Most children with ITP spontaneously recover. However, children with severe bleeding may require treatment. Traditional treatments such as corticosteroids or splenectomy are often associated with increased risks of infections. Currently, there is evidence that plat...
متن کاملThe biology of thrombopoietin and thrombopoietin receptor agonists.
Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. There is no "sensor" of the platelet count; rather TPO is produced in the liver at a constant rate and cleared by TPO receptors on platelets. TPO levels are inversely proportional to the rate...
متن کاملThrombopoietin level in patients with chronic liver diseases.
UNLABELLED Thrombocytopenia and oxidative stress are the most frequent problems in patients with chronic liver diseases as viral cirrhosis and schistosomiasis. So, this study aimed to evaluate the role of thrombopoietin (TPO) on the occurrence of thrombocytopenia and in differentiation between these diseases. It also aimed to investigate the relation between TPO, oxidative stress and antioxidan...
متن کاملUtility of Modeling End-Stage Liver Disease in Children with Chronic Liver Disease
Introduction: Chronic liver diseases consist of wide spectrum disorders that may be complicated by cirrhosis and therefore need to transplantation. The pediatric end-stage liver disease (PELD) score and model of end-stage liver disease (MELD) score has been used as predictors of mortality chronic liver diseases listed for liver transplantation. The aim of this study is evaluation of relation be...
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ژورنال
عنوان ژورنال: World Journal of Meta-Analysis
سال: 2020
ISSN: 2308-3840
DOI: 10.13105/wjma.v8.i3.220